Matrixx Initiatives to Webcast 2006 Annual Stockholder Meeting Thursday, May 11, 2006

PHOENIX, May 4 /PRNewswire-FirstCall/ -- Matrixx Initiatives, Inc. , a high growth, over-the-counter healthcare company that develops and markets products that provide consumers with "better ways to get better(R)," will host its 2006 Annual Stockholder Meeting at 10:00 a.m. PDT on Thursday, May 11, 2006 at the Ritz Carlton in Phoenix, Arizona. The purpose of the meeting is to elect four directors to the Company's board of directors and to ratify the appointment of Mayer Hoffman McCann P.C. as the independent registered public accounting firm for fiscal 2006. Following the formal meeting there will be a brief presentation regarding the Company's performance and growth strategy.

You may listen to the Annual Stockholder Meeting by calling [phone] (domestic) or [phone] (international). To listen to the Meeting and to view the accompanying slide presentation via the Internet, log onto http://www.matrixxinc.com/ and click on the Annual Stockholder Meeting icon. Please note that the broadcast will be listen-only.

A replay of the Meeting will be available at [phone] (domestic) or [phone] (international), access number 8868285 for 3 days following the call, and the web cast will be archived on the Company's website, http://www.matrixxinc.com/, for 30 days.

About Matrixx Initiatives, Inc.

Matrixx Initiatives, Inc. is engaged in the development, manufacture and marketing of over-the-counter healthcare products that utilize innovative drug delivery systems. Zicam, LLC, its wholly-owned subsidiary, produces, markets and sells Zicam(R) products in the cough and cold category, and recently launched a new brand, Nasal Comfort(TM), for nasal health. The Company's flagship product, Zicam Cold Remedy nasal gel, is a patented, homeopathic remedy that has been clinically proven to reduce the duration and severity of the common cold. In studies published in the October 2000 issue of ENT -- Ear, Nose and Throat Journal, and separately in the January 2003 issue of QJM: An International Journal of Medicine, the Zicam Cold Remedy product was shown to reduce the duration of the common cold. The Company also manufactures and markets a full line of Zicam brand pharmaceuticals, including Zicam Cold Remedy Chewables(TM); Zicam Cold Remedy Oral Mist(TM); Zicam Cold Remedy RapidMelts(TM); Zicam Allergy Relief; Zicam Cold Remedy Swabs(TM); Zicam Kids Size Cold Remedy Swabs(TM); Zicam Extreme Congestion Relief; Zicam Sinus Relief; Zicam Nasal Moisturizer, as well as seven Zicam Cough Mist(TM) products and four Zicam Cold & Flu relief items. For more information regarding Matrixx products, go to http://www.zicam.com/. To find out more about Matrixx Initiatives, Inc , visit our website at http://www.matrixxinc.com/. For additional information, contact William Hemelt, Chief Financial Officer, 602-385-8888, or Bill Barba, Manager of Investor Relations, at 602-385-8881. Matrixx is located at 4742 N. 24th Street, Suite 455, Phoenix, Arizona 85016.