DUBLIN, Mar. 03, 2015 /PRNewswire/ --Research and Markets
(http://www.researchandmarkets.com/research/rcv4lq/gene_therapy) has announced the addition of the "Gene Therapy Market, 2015 - 2025" report to their offering.
The "Gene Therapy Market, 2015-2025" report provides an extensive study on the marketed and pipeline gene therapies. A lot of research has been carried out in this field for over a decade but there are only five approved therapies (four available in Asian markets; one approved in the EU). There are many promising therapies which are currently being developed worldwide; the approach is likely to result in several commercial success stories in the foreseen future. The report covers various aspects, such as key players, marketed gene therapy products, products in clinical / pre-clinical research, associated ethical issues, likely future developments and upcoming opportunities for a variety of stakeholders.
Several disorders that arise inside the body are a result of either a direct genetic aberration or a dysfunctional/non-functional protein. The attempt to use nucleic acids to correct or delete the genes causing a particular disease is known as gene therapy. Although gene therapy has not contributed significantly to the global pharmaceutical market yet, it is anticipated to grow at a fast pace over the next decade.
Gendicine, developed by SiBiono GeneTech, was the foremost gene therapy that entered market in 2004 in China. Since then four more therapies have received approval in China, Philippines, Russia and the EU. This number for approved / marketed therapies seems weak at present; however, the strong and highly populated pipeline holds tremendous potential. There are 12 gene therapies in late stage of clinical development for the treatment of cancer, ocular and cardiovascular disorders.
There are several concerns that remain to be answered; examples include insertional mutagenesis, treatment of multigene disorders, curbing the risk of immune reactions, eugenics, high cost of therapy and ethical concerns related to making alterations at the genetic level. Despite this, gene therapy does offer a ray of hope for patients who either have no treatment options or show no benefits with drugs that are currently available. Such a benefit far outweighs any disadvantages that may be associated with this upcoming therapeutic field.
Key Topics Covered:
1. Preface
2. Executive Summary
3. Introduction
4. Viral and Non-Viral Vectors
5. Pipeline of Gene Therapy
6. Marketed Gene Therapies and Applications
7. Gene Therapy: Pipeline Products
8. Promising Therapeutics Areas
9. Gene Therapy: Additional Considerations
10. Conclusion
11. Interview Transcripts
12. Appendix 1: Tabulated Data
13. Appendix 2: List of Companies and Organisations
Companies Mentioned
- AAV Life
- Abeona Therapeutics
- ActoGenix
- Adaptimmune
- Aduro Biotech
- Advantagene
- Advaxis
- Aeras
- Alphavax
- Amgen
- AmphliPhi Biosciences
- Amsterdam Molecular Therapeutics
- Anaeropharma Science
- AnGes MG
- Applied Genetic Technologies Corp
- Asklepios BioPharmaceutical Inc.
- Astellas Pharma
- Audentes Therapeutics
- Avalanche Biotechnologies
- AveXis Inc
- Bavarian Nordic
- Baxter Healthcare Corporation
- Bellicum Pharmaceuticals
- Benitec BioPharma
- BioCancell
- Bioheart
- Biomics Biotechnologies
- Biontech
- Biovex
- Bluebird Bio
- BN ImmunoTherapeutics
- Calimmune
- Cardium Therapeutics
- Cell Therapy Catapult
- Celladon Corporation
- Ceregene
- ChiesiFarmaceutici
- ClinDatrix
- Cold Genesys, Inc.
- Crucell
- CytRx Corporation
- Daiichi Sankyo
- Diamyd Inc.
- Digna Biotech S.L.
- DNAtrix
- DNAVEC Corporation
- EGEN, Inc.
- Emergent Biosolutions
- Enzo Biochem
- Epeius Biotechnologies
- Errant Gene Therapeutics
- ESTEVE
- Etubics Corporation
- FKD Therapies Oy
- Fondazione Telethon
- Genable Technologies
- Gene Medicine Japan
- GeneCure Biotechnologies
- Genelux Corporation
- GeneOne Life Sciences
- GeneSight Biologics
- Genethon
- Genexine
- Genprex
- GenVec
- Genzyme
- GeoVax Inc.
- GlaxoSmithKline
- GlobeImmune
- Guangzhou DoublleBioproducts
- Gradalis Inc.
- Heat Biologics
- Helica Labs
- Herantis Pharma
- Ichor Medical Systems
- Imaxio
- Immune Design
- Inovio Pharmaceuticals
- Invivodata
- INVIVOGEN
- Ion Channel Innovations
- IrsiCaixa
- Isis Innovation
- Jennerex Biotherapeutics
- Juventas Therapeutics, Inc.
- Kolon Life Science
- LYSOGENE
- Marsala Biotech
- Medison Pharma
- Medigen Biotechnology Corporation
- Memgen Bio
- Merck
- Milo Biotechnology
- MiroVAX
- Mitsubishi Tanabe
- MolMed S.p.A
- Mologen AG
- Momotaro-Gene Inc
- MultiGene Vascular Systems
- NanoCor Therapeutics
- NEURALGENE
- Neurotech Pharmaceuticals
- Newlink Genetics Corporation
- Nightstar
- Novartis
- Oncolys BioPharma
- OncoSec Medical Incorporated
- Oncos Therapeutics
- Orca Therapeutics
- Oxford BioMedica
- Quintiles
- Pacific-Link Consulting
- Paragon Biomedical
- Pfizer
- PNP Therapeutics
- Profectus Biosciences
- Regen BioPharma
- Regeneron
- RegenX Biosciences
- ReiThera Sri
- REPLIcor
- Roche
- SanBio
- Sangamo Biosciences
- Sanofi
- Scancell Ltd
- Schering AG
- Shanghai Sunway Biotech
- SiBiono GeneTech
- SillaJen
- SironRX Therapeutics
- Spark Therapeutics
- SynerGene Therapeutics
- Tacere Therapeutics
- Takara Bio
- Theradex
- Theravectys S.A.
- Tocagen
- Transgene
- Treeway
- uniQure
- UCSF
- Vascular Biogenics
- Vaximm GmbH
- VCN Biosciences
- Vical
- ViroMed
- VIRxSYS Corporation
- Voyager Therapeutics
- VGXI
- Virttu Biologics
- Ziopharm
Organisations and Universities:
- Alpha-1 Foundation
- Assistance Publique - Hôpitaux de Paris; Paris 12 Val de Marne University; Université Paris VI
- ALS Therapy Development Institute
- Baylor College of Medicine
- Centro de InvestigaciónMédicaAplicada (CIMA)
- Children's Hospital Boston
- Children's Hospital of Philadelphia (CHOP)
- Choroideremia Research Foundation
- Christie Hospital NHS Foundation Trust Erasmus Medical Center
- City of Hope Medical Center
- Duke University Medical Center
- Erasmus Medical Center
- European and Developing Countries Clinical Trials Partnership (EDCTP)
- European Commission
- European Organisation for Research and Treatment of Cancer (EORTC)
- Fred Hutchinson Cancer Research Center; National Heart, Lung and Blood Institute (NHLBI)
- Goethe University
- Great Ormond Street Hospital for Children NHS Foundation Trust
- H. Lee Moffitt Cancer Center and Research Institute
- Hadassah Medical Organization
- Health Innovation Challenge Fund;
- Henry Ford Health System
- HIV Vaccine Trials Network (HVTN)
- Hospital InfantilUniversitario Niño Jesús
- Huazhong University of Science and Technology
- Human Stem Cells Institute
- Ichor Medical Systems
- Institut National de la Santé Et de la RechercheMédicale, France
- International AIDS Vaccine Initiative
- Jiangsu Province Hospital
- Jonsson Comprehensive Cancer Center
- King Khaled Eye Specialist Hospital
- Kuopio University Hospital
- Kyushu University Hospital
- Leukemia Lymphoma Research
- Loyola University
- M.D. Anderson Cancer Center
- Malaria Vectors Vaccines Consortium (MVVC)
- Massachusetts General Hospital
- Mayo Clinic
- Memorial Sloan-Kettering Cancer Center
- Mie University
- Milton S. Hershey Medical Center
- National Center for Research Resources
- National Eye Institute
- National Institute for Longevity Sciences of Japan
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Institute of Health (NIH)
- National Institute of Infectious Diseases of Japan
- National Institutes of Health Clinical Center (CC)
- National Taiwan University Hospital
- Nationwide Children's Hospital
- Naval Medical Research Center (NMRC)
- Cancer Research UK
- Memorial Sloan-Kettering Cancer Center
- Weill Medical College of Cornell University
- Oregon Health and Science University
- Phase One Foundation
- Public Health Agency of Canada
- ReiTheraSrl
- Research Center for Hematology of the Russian Ministry of Healthcare
- Rockefeller University
- Royal Brompton &Harefield NHS Foundation Trust
- Sidney Kimmel Comprehensive Cancer Center
- Shanxi Taxus Pharmaceuticals
- St. Jude Children's Research Hospital
- Stanford University
- Stichting Het NederlandsKankerInstituut
- Sun Yat-Sen University Cancer Center
- Swedish Institute for Infectious Disease Control
- Texas Children's Hospital
- The Ellis Lab; University of Texas Southwestern
- The Methodist Hospital System
- The University of Kansas Medical Center
- Tianjin Medical University Cancer Institute and Hospital
- Tumor Hospital of Medical Sciences Academy of China
- United Kingdom Cystic Fibrosis Gene Therapy Consortium
- Universidad de Navarra
- University College London
- University Hospital Birmingham
- University of Alabama at Birmingham
- University of Birmingham
- University of California, Berkeley
- University of Cambridge
- University of Connecticut
- University of Florida
- University of Miami
- University of Michigan
- University of Nairobi
- University of Nebraska Medical Center
- University of New South Wales
- University of Oxford
- University of Pennsylvania
- University of Pittsburgh
- University of Southern California
- University of Tennessee
- University of Texas
- University of Tokyo Hospital
- University of Washington
- University of Wisconsin
- University of Zurich
- Uppsala University Hospital
- Wayne State University
- West China Hospital
- WuxiAppTec
For more information visit http://www.researchandmarkets.com/research/rcv4lq/gene_therapy
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