BASEL (dpa-AFX) - Novartis' (NVS) early stage histology data in kidney transplantation suggests that its investigational compound Iscalimab maybe capable of prolonging the durability of transplanted kidneys as well as potentially improving long-term outcomes for kidney transplant patients.
The findings are to be confirmed in an ongoing phase IIb trial.
According to the data, three of five (60%) of Iscalimab-treated transplant patients have normal kidney histology at least 1 year after transplant compared to none of seven (0%) patients treated with Tacrolimus, the current standard of care.
'Extending the life of transplanted kidneys would mean fewer patients going back on dialysis or needing a second transplant - relieving pressure on waiting lists that in the US are already three-to-five years long,' said Eric Hughes, Global Development Unit Head, Immunology, Hepatology and Dermatology.
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