Study to identify genomic markers associated with clinical response to ADCT-402 (loncastuximab tesirine) in relapsed or refractory diffuse large B-cell lymphoma (DLBCL)
LAUSANNE, Switzerland, Aug. 06, 2019 (GLOBE NEWSWIRE) -- ADC Therapeutics, an oncology drug discovery and development company that specializes in the development of antibody drug conjugates (ADCs), and SOPHiA GENETICS, a leader in Data-Driven Medicine, today announced they have entered into a collaboration to identify genomic markers associated with clinical response to ADCT-402 (loncastuximab tesirine). ADC Therapeutics is currently evaluating ADCT-402 in a pivotal Phase II clinical trial in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
SOPHiA GENETICS will conduct somatic mutation analysis of more than 4,000 genes in cell-free DNA (cfDNA) samples extracted from blood of DLBCL patients participating in ADC Therapeutics' Phase II trial. SOPHiA technology will match detected genomic markers with clinical response to ADCT-402. The analytical power of SOPHiA for the detection of cancer mutations is key for this new development phase and illustrates the benefits of adopting Data-Driven Medicine applications for clinical trials.
"Our collaboration with SOPHiA GENETICS has the potential to uncover genomic mutations that correlate with clinical response to ADCT-402," stated Patrick van Berkel, Senior Vice President of Research and Development at ADC Therapeutics. "We have observed significant single-agent clinical activity in our pivotal Phase II trial of ADCT-402 in a broad population of patients with relapsed or refractory diffuse large B-cell lymphoma. The insights from this collaboration will allow us to better identify and understand the characteristics of patients who respond best to treatment. We look forward to the results of this research enabled by SOPHiA's unique platform."
"We are pleased to partner with ADC Therapeutics, a leader in antibody drug conjugate development, to provide advanced biomarker analysis and turn the results into actionable insights that can improve clinical outcomes for patients and pave the way towards a new era in drug development," said Esteban Czwan, Senior Vice President BioPharma at SOPHiA GENETICS.
Financial terms of the collaboration were not disclosed.
About ADCT-402
ADCT-402), a Phase Ib trial in combination with ibrutinib in patients with R/R DLBCL or mantle cell lymphoma) and a Phase Ib trial in combination with durvalumab in patients with R/R DLBCL, MCL or follicular lymphoma). The U.S. Food and Drug Administration granted orphan drug designation to ADCT-402 for the treatment of relapsed or refractory DLBCL and MCL.
About ADC Therapeutics
ADC Therapeutics SA is an oncology drug discovery and development company that specializes in the development of highly targeted antibody drug conjugates.
About SOPHiA GENETICS
SOPHiA GENETICS is a health tech company that developed SOPHiA, an advanced AI technology helping healthcare professionals make sense of the large amount of clinical data. SOPHiA GENETICS is democratizing Data-Driven Medicine by enabling the rapid adoption of genomic and radiomic analysis worldwide, turning data into actionable insights, and sharing knowledge through its community of 980 healthcare institutions in 81 countries in a sustainable and inclusive way. The company's achievements and innovative approach is recognized by the MIT Technology Review "50 Smartest Companies."
| ADC Therapeutics Contacts | ||
| Investors Contact Dr. Chris Martin Chief Executive Officer Chris.martin@adctherapeutics.com (mailto:Chris.martin@adctherapeutics.com) Tel.: +41 (0) 21 653 0200 | EU Media Contact Alexandre Müller Dynamics Group amu@dynamicsgroup.ch (mailto:amu@dynamicsgroup.ch)Tel: +41 (0) 43 268 3231 | USA Media Contact Tony Plohoros 6 Degrees tplohoros@6degreespr.com (mailto:tplohoros@6degreespr.com) Tel.: +1 908-591-2839 |
| SOPHiA GENETICS Contacts | ||
| EU Media Contact Sophie Reymond Media Relations Officer sreymond@sophiagenetics.com (mailto:sreymond@sophiagenetics.com) Tel.: +41 (0) 21 694 10 75 | USA Media Contact Don Granese Media Relations Specialist dgranese@sophiagenetics.com (mailto:dgranese@sophiagenetics.com) Tel: +1 857-263-7972 | |
