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WKN: A1XE7A | ISIN: CA4990531069 | Ticker-Symbol: 04K
Tradegate
03.11.25 | 15:36
3,640 Euro
+1,11 % +0,040
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Pharma
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Knight Therapeutics Reports Third Quarter 2025 Results

Achieved record-high quarterly revenues, Adjusted EBITDA1 and Adjusted EBITDA per share1 since inception
Increased 2025 financial guidance

MONTREAL, Nov. 06, 2025 (GLOBE NEWSWIRE) -- Knight Therapeutics Inc. (TSX: GUD) ("Knight" or "the Company"), a pan-American (ex-US) specialty pharmaceutical company, today reported financial results for its third quarter ended September 30, 2025. All currency amounts are in thousands except for share and per share amounts. All currencies are Canadian unless otherwise specified.

Q3-25 Highlights

Financial results

  • Revenues were $121,548, an increase of $29,285 or 32% over the same period in prior year. The increase was primarily driven by the incremental revenues from the Paladin and Sumitomo Transactions and the growth of our key promoted products.
  • Gross margin was $55,810 or 46% of revenues compared to $45,017 or 49% of revenues in the same period in prior year. This increase in gross margin was mainly due to the contribution from the Paladin and Sumitomo portfolios.
  • Operating income was $646 compared to $3,203 in the same period in prior year.
  • Net loss was $3,791, compared to a net income of $85 in the same period in prior year.
  • Net loss per share was $0.04, compared to nil in the same period in prior year.
  • Cash inflow from operations was $10,163, compared to $5,016 in the same period in prior year.

Non-GAAP measures

  • Adjusted Revenues1 were $122,628, an increase of $31,198 or 34% over the same period in prior year, or $29,324 or 31% on a constant currency1 basis, primarily driven by the incremental revenues from the Paladin and Sumitomo Transactions and the growth of our key promoted products.
  • Excluding products acquired during the year, the innovative promoted portfolio delivered organic growth of 12% on a constant currency1 basis during the nine-month period ending September 30, 2025.
  • Adjusted Gross Margin1 was $59,898 or 49% of Adjusted Revenues1 compared to $43,196 or 47% of Adjusted Revenues1 in the same period in prior year. The increase in the Adjusted Gross Margin1 and Adjusted Gross Margin1 %, was mainly due to the contribution from the Paladin and Sumitomo portfolios.
  • Adjusted EBITDA1 was $20,987, an increase of $7,533 or 56% over the same period in prior year.
  • Adjusted EBITDA per share1 was $0.21, an increase of $0.08 or 62% over the same period in prior year.

__________________
1 Adjusted Revenues, revenues at constant currency, Adjusted Gross Margin, Adjusted EBITDA and Adjusted EBITDA per share are non-GAAP measures and do not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to section - Financial Results under Non-GAAP measures for additional details.

Corporate developments

  • Launched an NCIB to purchase up to 3,000,000 common shares of the Company over the next 12 months.
  • Collected strategic loan receivable with a life sciences company for $3,840 (US$2,771).

Products

  • Amended the Supply and Distribution Agreement with Incyte to add the exclusive rights to distribute ZYNYZ (retifanlimab) and NIKTIMVO (axatilimab) in Latin America.
  • Relaunched Myfembree® (relugolix/estradiol/norethindrone acetate) and Orgovyx® (relugolix) in Canada.
  • Received rejection from ANVISA regarding the marketing authorization application for Tavalisse® (fostamatinib) in Brazil and has submitted an appeal to ANVISA subsequent to the quarter.

Subsequent to quarter-end

  • Obtained regulatory approval and launched Minjuvi® (tafasitamab) in Argentina.
  • Launched Jornay PM (methylphenidate HCI extended-release capsules) in Canada.
  • Launched Pemazyre® (pemigatinib) in Brazil and Mexico.
  • Received Notice of Non-Compliance from Health Canada requesting additional information for its New Drug Submission for Qelbree® (viloxazine) and will submit the response in 2026.
  • Closed syndication process with four lenders and doubled size of secured revolving credit facility from US$50 million to US$100 million with an accordion feature of US$100 million.
  • Purchased 388,700 common shares through Knight's NCIB at an average purchase price of $5.84 for an aggregate cash consideration of $2,272.

"I am pleased to announce that for the first nine months of 2025, we achieved record-high adjusted revenues1 of $319 million and adjusted EBITDA1 of approximately $49 million. These record results underscore the successful integration of the Paladin and Sumitomo portfolios, which strengthened our Canadian operations and drove meaningful contribution. In addition, our innovative promoted product portfolio delivered 12% of organic growth on a constant currency1 basis. Beyond financial performance, we advanced and expanded our pipeline with the launches of Jornay PM in Canada, Minjuvi® in Argentina and Pemazyre® in Brazil and Mexico and strengthened our partnership with Incyte by adding retifanlimab and axatilimab. While we experienced regulatory setbacks for Qelbree® in Canada and Tavalisse® in Brazil, we will respond to the agencies' requests and expect to bring these drugs to market. In addition, subsequent to quarter-end, we doubled the size of our revolving credit facility to US$100 million with an accordion feature of an additional US$100 million. This facility provides us with the financial flexibility to continue to transact and grow our business." said Samira Sakhia, President and CEO of Knight Therapeutics Inc.

____________________
1 Adjusted revenues, revenues at constant currency and adjusted EBITDA are non-GAAP measures and do not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to section - Financial Results under Non-GAAP measures for additional details.

SELECT FINANCIAL RESULTS REPORTED UNDER IFRS
[In thousands of Canadian dollars]
Change Change
Q3-25Q3-24$1 %2YTD-25YTD-24$1 %2
Revenues121,548 92,263 29,285 32%316,982 274,440 42,542 16%
Gross margin55,810 45,017 10,793 24%135,507 134,053 1,454 1%
Gross margin %46%49% 43%49%
Selling and marketing17,908 13,372 (4,536)34%47,506 39,285 (8,221)21%
General and administrative13,116 12,110 (1,006)8%41,149 34,747 (6,402)18%
Research and development8,694 5,153 (3,541)69%19,761 15,939 (3,822)24%
Amortization of intangible assets15,446 11,179 (4,267)38%35,651 33,725 (1,926)6%
Operating expenses55,164 41,814 (13,350)32%144,067 123,696 (20,371)16%
Operating income (loss)646 3,203 (2,557)80%(8,560)10,357 (18,917)183%
Net (loss) income(3,791)85 (3,876)4560%(14,228)(6,403) (7,825)122%

1. A positive variance represents a positive impact to net income (loss) and a negative variance represents a negative impact to net income (loss).

2. Percentage change is presented in absolute values.

Revenues: For the quarter ended September 30, 2025, revenues increased by $29,285 or 32% compared to the same period in prior year, including a reduction in revenues of $1,913 due to the Hyperinflation Impact1. Excluding IAS 29, the increase was $31,198 or 34% and $29,324 or 31% on a constant currency2 basis. The Paladin and Sumitomo portfolios contributed to $24,961 of incremental revenues. The remaining variance was mainly driven by our key promoted products which grew by $5,497, or 8% on a constant currency2 basis, and purchasing patterns of certain products, partly offset by declines in our mature and branded generic products and the termination of a non-strategic agreement in Colombia.

Our revenues by therapeutic area is as follows:

Change
Therapeutic AreaQ3-25Q3-24$%
Oncology/Hematology37,75237,2954571%
Infectious Diseases36,84034,0402,8008%
Other Specialty46,95620,92826,028124%
Total121,54892,26329,28532%

____________________
1 The Hyperinflation Impact is due to the application of IAS 29 in Argentina. Refer to section - Hyperinflation for additional details.
2 Revenues at constant currency is a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to section - Financial Results under Non-GAAP measures for additional details.

The increase in revenues is explained by the following:

  • Oncology/Hematology: The oncology/hematology portfolio increased by $457 or 1%. Excluding the termination of a non-strategic distribution agreement in Colombia in December 2024, for the quarter ended September 30, 2025, the oncology/hematology portfolio increased by $1,632 or 4%, which included a reduction in revenues of $1,004 due to the Hyperinflation Impact1. Excluding IAS 29, the oncology/hematology portfolio increased by $2,636 or 7% and $689 or 2% on a constant currency2 basis. The increase was due to the growth of our key promoted products of $2,807 or 15% on a constant currency2 basis, mainly driven by the growth of Akynzeo®, the launch of Minjuvi®, the addition of Orgovyx® and Onicit®. This growth was partly offset by declines in our mature and branded generics products due to their lifecycle.

  • Infectious Diseases: For the quarter ended September 30, 2025, the infectious diseases portfolio increased by $2,800 or 8%, which included a reduction in revenues of $599 due to the Hyperinflation Impact1. Excluding IAS 29, the infectious diseases portfolio increased by $3,399 or 10% and $2,256 or 6% on a constant currency2 basis. The increase was mainly due to the growth of Cresemba® and the purchasing patterns of certain products.

The Company signed the following contracts with the MOH for Ambisome®, with the following deliveries:

ContractDelivered
YearTotalYTD-25202420232022Total
2022$34,600-$2,400$25,200$7,000$34,600
2024$22,400-$22,400--$22,400
2025$32,229$32,229---$32,229
Total$89,229$32,229$24,800$25,200$7,000$89,229
Q3-25 vs Q3-24 and YTD-25 vs YTD-24
Contract
Year
Q3-25Q3-24YTD-25YTD-24
2022---$2,400
2024-$6,700-$22,400
2025- -$32,229-
Total-$6,700$32,229$24,800
  • Other Specialty: For the quarter ended September 30, 2025, the other specialty portfolio increased by $26,028 or 124%, which included a reduction in revenues of $310 due to the Hyperinflation Impact1. Excluding IAS 29, the other specialty portfolio increased by $26,338 or 127% and $26,379 or 127% on a constant currency2 basis. The Paladin and Sumitomo portfolios contributed to $23,433 of incremental revenues. The remaining variance was mainly driven by the launch of Imvexxy® and Bijuva® and the purchasing patterns of certain customers.

___________________
1 The Hyperinflation Impact is due to the application of IAS 29 in Argentina. Refer to section - Hyperinflation for additional details.
2 Revenues at constant currency is a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to section - Financial Results under Non-GAAP measures for additional details.

Gross margin: For the quarter ended September 30, 2025, gross margin was $55,810 or 46% compared to $45,017 or 49% in Q3-24. The gross margin was negatively impacted by $3,838 due to the Hyperinflation Impact1 as well as $2,071 due to the Step-Up Expense2 on the Paladin Transaction. Excluding the Hyperinflation Impact1 and the Step-Up Expense2, the Adjusted Gross Margin3 was $59,898 in Q3-25, an increase of $16,702 compared to Q3-24, mainly driven by the Paladin and Sumitomo portfolios. The Adjusted Gross Margin3 as a % of Adjusted Revenues3, was 49% in Q3-25 compared to 47% in Q3-24. The increase was driven by the higher contribution of the Canadian business in Q3-25 compared to Q3-24, which generates a higher Adjusted Gross Margin as a % of Adjusted Revenues3.

Selling and marketing ("S&M") expenses: For the quarter ended September 30, 2025, S&M expenses increased by $4,536 or 34%, which included a reduction of expenses of $423 due to the Hyperinflation Impact1. Excluding IAS 29, selling and marketing expenses increased by $4,959 or 38%. The increase was driven by an increase in our sales and commercial structure behind the addition of the Paladin and Sumitomo portfolios as well as the launch of Minjuvi® in Mexico and Jornay PM in Canada. In addition, the increase also included our promotion and marketing expenses for the newly launched brands acquired in our Paladin and Sumitomo Transactions including Orgovyx®, Myfembree®, Xcopri® and Envarsus® PA as well as spending on our pre-launch and recently launched brands including Jornay PM and Imvexxy® in Canada, Minjuvi® in Mexico and Argentina and Tavalisse® in Mexico.

General and administrative ("G&A") expenses: For the quarter ended September 30, 2025, G&A expenses increased by $1,006 or 8%, which included an increase of expenses of $234 is due to the Hyperinflation Impact1. Excluding IAS 29, general and administrative expenses increased by $772 or 6%. The increase was mainly due to an increase of $680 in share-based compensation mainly as a result of periodic reassessment of vesting targets.

Research and development ("R&D") expenses: For the quarter ended September 30, 2025, R&D expenses increased by $3,541 or 69%, which included an increase of expenses of $58 due to the Hyperinflation Impact1. Excluding IAS 29, R&D expenses increased by $3,483 or 65%. The increase was mainly due to the expansion of our scientific affairs structure including field-based medical science liaison personnel related to the Paladin and Sumitomo portfolios. In addition to structure, the increase included incremental medical, regulatory and pharmacovigilance spend on the Paladin and Sumitomo portfolios as well as on our pipeline and launches including Qelbree®, Jornay PM and Pemazyre®.

Net loss
For the quarter ended September 30, 2025, the net loss was $3,791 compared to net income of $85 for the same period in prior year. The variance mainly resulted from the above-mentioned items and (1) an income tax expense of $1,874 in Q3-25 compared to an income tax expense of $523 in Q3-24, (2) a net loss of $4,589 on the revaluation of financial assets measured at fair value through profit or loss in Q3-25 versus a net loss of $2,820 in the same period in prior year, (3) an interest income of $1,107 in Q3-25 compared to $2,523 in the same period in prior year, due to a repayment of the Synergy loan and a lower average balance of marketable securities, (4) gain on hyperinflation of $434 in Q3-25 compared to a gain on hyperinflation of $1,148 in Q3-24, and (5) a foreign exchange gain of $3,124 in Q3-25 mainly driven by the revaluation of intercompany balances due to the appreciation of the BRL and COP vs USD, compared to a foreign exchange loss of $2,326 in Q3-24 mainly driven by the appreciation of CAD vs USD.

____________________
1 The Hyperinflation Impact is due to the application of IAS 29 in Argentina. Refer to section - Hyperinflation for additional details.
2 Step-Up Expense is defined as the impact in cost of goods sold of the difference between the fair value of inventory acquired and the cost paid in the Paladin Transaction, accounted under IFRS 3 - Business Combinations, when the inventory acquired as part of the transaction is sold.
3 Adjusted Revenues and Adjusted Gross Margin are non-GAAP measures and do not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to Section 8 - Financial Results under Non-GAAP measures for additional details.

SELECT BALANCE SHEET ITEMS
[In thousands of Canadian dollars]
Change
September 30,
2025
December 31,
2024
$%
Cash, cash equivalents and marketable securities95,558142,331(46,773)33%
Trade and other receivables171,440154,51816,922 11%
Inventories144,401102,69841,703 41%
Financial assets94,492133,932(39,440)29%
Intangible assets377,417283,61293,805 33%
Accounts payable and accrued liabilities118,12883,17334,955 42%
Bank loans96,54543,38553,160 123%


Cash, cash equivalents and marketable securities
: As at September 30, 2025, Knight had $95,558 in cash, cash equivalents and marketable securities, a decrease of $46,773 or 33%, as compared to December 31, 2024. The decrease is mainly driven by the payment of $140,318 for the Paladin and Sumitomo Transactions, the repayment of principal and interest on bank loans and lease liabilities of $17,048, the repurchase of common shares through the NCIB for $3,351, partly offset by cash inflows from operations of $34,085, the drawdown of $60,000 from the NBC revolving credit facility, as well as collection from loan repayments and distribution from funds of $23,268.

Trade and other receivables: As at September 30, 2025, Trade and other receivables were $171,440, an increase of $16,922 or 11%, as compared to December 31, 2024, mainly due to the trade receivables related to the revenues from the Paladin and Sumitomo portfolios, partly offset by the timing of collections from certain customers.

Inventories: As at September 30, 2025, Inventory were $144,401, an increase of $41,703 or 41%, as compared to December 31, 2024, of which approximately $25,000 was driven by the inventory related the Paladin and Sumitomo portfolios. The remaining variance was due to the timing of purchases as well as investments on our new product launches, partly offset by the hyperinflation impact under IAS 29 on inventory held in Argentina as well as foreign exchange revaluation.

Financial assets: As at September 30, 2025, financial assets were $94,492, a decrease of $39,440 or 29%, as compared to December 31, 2024. This decrease was driven by strategic loan repayments of $21,116 and a decrease in fund investments of $20,115, which included a decrease in fair value of $14,457 and a return of capital of $5,658.

Intangible assets: As at September 30, 2025, intangible assets were $377,417, an increase of $93,805 or 33%, as compared to December 31, 2024, mainly due to the recognition of the intangible assets acquired in the Paladin Transaction for $96,506 and the Sumitomo Transaction for $29,708, partly offset by amortization, foreign exchange revaluation and the de-recognition of certain milestones not expected to be met.

Accounts payable and accrued liabilities: As at September 30, 2025, accounts payable and accrued liabilities were $118,128, an increase of $34,955 or 42%, as compared to December 31, 2024, driven by a higher level of payables in our Canadian operations due to the increase in the portfolio as a result of the Paladin and Sumitomo Transactions, as well as the purchase of inventory for our key promoted products.

Bank Loans: As at September 30, 2025, bank loans were $96,545, an increase of $53,160 or 123%, as compared to December 31, 2024, mainly driven by the drawdown of $60,000 from the NBC revolving credit facility on June 17, 2025 and foreign exchange revaluation of $1,019, partly offset by net repayments of $7,859 mainly on the IFC and Bancolombia loans.

Product Updates

Retifanlimab and axatilimab

In Q3-25, Knight expanded its relationship with Incyte Biosciences International Sàrl, the Swiss-based affiliate of Incyte, for the exclusive rights to distribute retifanlimab (sold as ZYNYZ® in the United States and Europe) and axatilimab (sold as NIKTIMVO® in the United States) for Latin America.

Myfembree® (relugolix/estradiol/norethindrone acetate)

Myfembree® is a fixed-dose combination of relugolix, estradiol, and norethindrone acetate and is the first oral prescription treatment for both the management of heavy menstrual bleeding associated with uterine fibroids and the management of moderate to severe pain associated with endometriosis in pre-menopausal women.1 In Q3-25, Knight relaunched Myfembree® in Canada.

Orgovyx® (relugolix)

Orgovyx® is the first and only oral gonadotropin-releasing hormone receptor, or GnRH, antagonist approved by Health Canada for the treatment of adult patients with advanced prostate cancer.2 In Q3-25, Knight relaunched Orgovyx® in Canada.

Minjuvi® (tafasitamab)

In October 2025, Knight obtained regulatory approval and launched Minjuvi® in Argentina, for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma ("DLBCL") who are not eligible for autologous stem cell transplantation ("ASCT").

Jornay PM (methylphenidate HCI extended-release capsules)

Jornay PM is the first and only evening-dosed methylphenidate product commercially available in Canada to treat Attention-Deficit Hyperactivity Disorder ("ADHD") in patients from 6 to 12 years of age. Jornay PM consists of microbeads with a delayed-release layer and an extended-release layer. The first layer delays the release of the active ingredient until morning while the extended-release layer controls the release of the active ingredient starting in the morning and continuing throughout the day. This unique formulation provides a pharmacokinetic profile that allows ADHD symptom control from the time patients wake up until the evening.

On October 30, 2025, Knight announced the launch of Jornay PM in Canada.

Pemazyre® (pemigatinib)

Subsequent to the quarter, Knight launched Pemazyre® in Mexico and Brazil, for the treatment of adults with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 ("FGFR2") fusion or rearrangement that have progressed after at least one prior line of systemic therapy.

Tavalisse® (fostamatinib)

In September 2025, Knight received a rejection from ANVISA regarding its marketing authorization application for Tavalisse® in Brazil. Subsequent to the quarter, Knight filed an appeal with ANVISA, a process that may take up to fourteen months.

Qelbree® (viloxazine)

Subsequent to the quarter, Knight received a Notice of Non-Compliance (NON) from Health Canada for its New Drug Submission for Qelbree®, for the treatment of ADHD. Knight will submit its response to Health Canada in 2026 and expects to obtain the regulatory approval of Qelbree®.

____________________
1 MYFEMBREE® Product Monograph. Paladin Labs Inc. October 13, 2023.
2 ORGOVYX
®Product Monograph. Paladin Labs Inc. October 6, 2023.

Corporate Updates

NCIB

On August 20, 2025, the Company commenced an NCIB where Knight may purchase for cancellation up to 3,000,000 common shares of the Company. During the three-month period ended September 30, 2025, the Company purchased no common shares, and during the nine-month period ended September 30, 2025, the Company purchased 606,400 (2024: 437,500 and 643,161) common shares, at an average price of $5.53 (2024: $5.65 and $5.78) for aggregate cash consideration of $3,351 (2024: $2,474 and $3,716). Subsequent to quarter-end up to October 30, 2025, the Company purchased an additional 388,700 common shares at an average purchase price of $5.84 for an aggregate cash consideration of $2,272.

Revolving Credit Facility

On June 17, 2025, Knight entered into a secured revolving credit facility with NBC for a total amount of US$50,000 [$68,215], of which $60,000 was withdrawn at closing to fund a portion of the Paladin Transaction. Subsequent to quarter-end, on October 31, 2025, Knight closed the syndication of its Credit Facility. As part of the syndication process, three additional banks were included as Lenders: Citibank N.A., CIBC, and TD (together with NBC, the "Lenders"). The syndicate has four banks, with NBC as the Lead Arranger. The Credit Facility was increased to US$100,000, ("Credit Facility") with an accordion feature for an additional US$100,000, subject to receipt of acceptance by the Lenders.

The Credit Facility is secured by Knight's assets held in Canada, Luxembourg and Uruguay, and has an initial term of 3 years, with the option to extend annually for an additional one-year term. The Credit Facility is subject to customary stand-by fees for the undisbursed portion and can be drawn in USD or CAD at the SOFR or CORRA rate plus an applicable margin between 1.25% to 2.75% depending on Knight's debt leverage.

Financial Outlook1

For fiscal 2025, Knight has increased its financial guidance on revenues and adjusted EBITDA2 as a % of revenues. The Company expects to generate between $430 million to $440 million in revenues up from $410 to $420 million and adjusted EBITDA2 is expected to be between 13.5% to 14.5% of revenues up from 13%. The increase in our outlook is driven by the performance of our promoted products. The guidance is based on a number of assumptions, including but not limited to the following:

  • no material impact on revenues due to the application of hyperinflation accounting for Argentina
  • no revenues for business development transactions not completed as at November 5, 2025
  • no unforeseen termination to our license, distribution & supply agreements
  • no interruptions in supply whether due to global supply chain disruptions or general manufacturing issues
  • no new generic entrants on our key pharmaceutical brands
  • no unforeseen changes to government mandated pricing regulations
  • successful commercial execution on product listing arrangements with HMOs, insurers, key accounts, and public payers
  • successful execution and uptake of newly launched products
  • no material increase in provisions for inventory or trade receivables
  • no significant variations of forecasted foreign currency exchange rates
  • inflation remaining within forecasted ranges

Should any of the assumptions differ, the financial outlook and the actual results may vary materially. Refer to the risks and assumptions referred to in the Forward-Looking Statements section of this news release for further details.

____________________
1 This forward looking information is based on assumptions specific to the nature of the Company's activities with regard to annual revenue growth considering industry information, expected market share, pricing assumptions, actions of competitors, sales erosion rates after the end of patent or other intellectual property rights protection, the timing of the entry of generic competition, the expected results of tenders, among other variables.
2 Adjusted EBITDA is a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies. Refer to section Financial Results under Non-GAAP measures for additional details.

Conference Call Notice

Knight will host a conference call and audio webcast to discuss its third quarter ended September 30, 2025, today at 8:30 am ET. Knight cordially invites all interested parties to participate in this call.

Date: Thursday, November 6, 2025
Time: 8:30 a.m. ET
Telephone: Toll Free: 1-888-699-1199 or International 1-416-945-7677
Webcast: www.knighttx.com or Webcast
This is a listen-only audio webcast. Media Player is required to listen to the broadcast.

Replay: An archived replay will be available for 30 days at www.knighttx.com.

About Knight Therapeutics Inc.

Knight Therapeutics Inc., headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring or in-licensing and commercializing pharmaceutical products for Canada and Latin America. Knight's Latin American subsidiaries operate under United Medical, Biotoscana Farma and Laboratorio LKM. Knight Therapeutics Inc.'s shares trade on TSX under the symbol GUD. For more information about Knight Therapeutics Inc., please visit the company's web site at www.knighttx.com or www.sedarplus.ca.

Forward-Looking Statement

This document contains forward-looking statements for Knight Therapeutics Inc. and its subsidiaries. These forward-looking statements, by their nature, necessarily involve risks and uncertainties that could cause actual results to differ materially from those contemplated by the forward-looking statements. Knight Therapeutics Inc. considers the assumptions on which these forward-looking statements are based to be reasonable at the time they were prepared but cautions the reader that these assumptions regarding future events, many of which are beyond the control of Knight Therapeutics Inc. and its subsidiaries, may ultimately prove to be incorrect. Factors and risks, which could cause actual results to differ materially from current expectations are discussed in Knight Therapeutics Inc.'s Annual Report and in Knight Therapeutics Inc.'s Annual Information Form for the year ended December 31, 2024 as filed on www.sedarplus.ca. Knight Therapeutics Inc. disclaims any intention or obligation to update or revise any forward-looking statements whether because of new information or future events, except as required by law.

CONTACT INFORMATION:

Investor Contact:
Knight Therapeutics Inc.
Samira SakhiaArvind Utchanah
President & Chief Executive OfficerChief Financial Officer
T: 514.484.4483T. +598.2626.2344
F: 514.481.4116
Email: IR@knighttx.comEmail: IR@knighttx.com
Website: www.knighttx.comWebsite: www.knighttx.com

HYPERINFLATION

The Company applies IAS 29, Financial Reporting in Hyperinflation Economies, as the Company's Argentine subsidiary uses the Argentine Peso as its functional currency. IAS 29 requires that the financial statements of an entity whose functional currency is the currency of a hyperinflationary economy be adjusted based on an appropriate general price index to express the effects of inflation. After applying for the effects of hyperinflation, the statement of income (loss) is converted using the closing foreign exchange rate of the month.

Revenues and operating expenses in the local currency, i.e. ARS, are restated from the month of the sales or the month in which the expense was incurred to the end of the reporting period using the inflation index during that period. The restatement calculation is performed on a year to date basis based on IAS29 ("Inflation Adjusted Figures"). For the nine-month period ended September 30, 2025 and 2024, the Company applied the following inflation index for the restatement of each respective month.

JanuaryFebruaryMarchAprilMayJuneJulyAugustSeptember
20251.191.171.121.091.081.061.041.021.00
20241.671.481.331.221.171.121.081.041.00

Under IAS 29, the translation from the local currency, to the reporting currency is performed on the Inflation Adjusted Figures using the end of period rate at the reporting date. The Inflation Adjusted Figures were converted to CAD using the following quarter-end closing rates for each of the respective periods.

Q3-25Q3-24
ARS981716
Q3-25Q3-24YTD-25YTD-24
ARS Variation %1(12)%(8)%(37)%(17)%

1 Depreciation of ARS vs CAD during each period, calculated as follows: (End of period rate - Beginning of period rate) / Beginning of period rate.

In Q3-25 and YTD-25, the inflation rate used for the hyperinflation adjustments on revenues and operating expenses for the Company's subsidiary in Argentina was lower than the ARS depreciation in the same period. For example, the revenues generated and operating expenses incurred in January 2025 were restated by applying an inflation index of 19% while the ARS to CAD depreciated by 37% in YTD-25. Consequently, this resulted in lower revenues and operating expenses reported under IAS 29 in CAD. Conversely, in Q3-24 and YTD-24, the inflation index was higher than the ARS depreciation which resulted in higher revenues and operating expenses reported under IAS 29 in CAD. Therefore, the hyperinflation accounting under IAS 29 resulted in a decrease in the reported revenues and operating expenses for the Company's subsidiary in Argentina in CAD in both Q3-25 and YTD-25 when compared to the same periods in prior year ("Hyperinflation Impact").

Under hyperinflation accounting, the cost of goods sold in the local currency, i.e. ARS, is restated using the inflation index from the purchase or manufacturing date to the end of the reporting period, and are converted to CAD using the respective quarter-end closing rates. In Q3-25 and YTD-25, the cumulative inflation index applied on the inventory sold was higher than the prior year periods, leading to higher cost of goods sold reported under IAS 29 in CAD and consequently a lower gross margin both in Q3-25 and YTD-25 compared to the same periods in prior year ("Gross Margin Hyperinflation Impact").

FINANCIAL RESULTS UNDER NON-GAAP MEASURES
[In thousands of Canadian dollars]

The Company discloses non-GAAP measures and ratios that do not have standardized meanings prescribed by IFRS. The Company believes that shareholders, investment analysts and other readers find such measures helpful in understanding the Company's financial performance. Non-GAAP financial measures and adjusted EBITDA per share ratio do not have any standardized meaning prescribed by IFRS and may not have been calculated in the same way as similarly named financial measures presented by other companies. The Company uses the following non-GAAP measures.

[i] Financial results excluding the impacts of hyperinflation under IAS 29

The Company applies IAS 29, Financial Reporting in Hyperinflation Economies, as the Company's Argentine subsidiary used the Argentine Peso as their functional currency. IAS 29 requires that the financial statements of an entity whose functional currency is the currency of a hyperinflationary economy be adjusted based on an appropriate general price index to express the effects of inflation.

Financial results under IFRS are adjusted to remove the impact of hyperinflation under IAS 29. The impact of hyperinflation under IAS 29 is calculated by applying an appropriate general price index to express the effects of inflation. After applying the effects of translation, the statement of income is converted using the closing foreign exchange rate of the month.

The Company believes that financial results excluding the impact of hyperinflation under IAS 29 represents a useful measure to investors as they allow results to be viewed without those impacts, thereby facilitating the comparison of results period over period. The presentation of financial results excluding the impact of hyperinflation under IAS 29 is considered to be a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

The following tables reconcile the financial results under IFRS to financial results excluding the impact of hyperinflation under IAS 29.

Q3-25YTD-25
Reported under IFRS

IAS 29 Adjustment

Excluding the Impacts of
IAS 29

Reported under IFRS

IAS 29 Adjustment

Excluding the Impacts of
IAS 29

Revenues121,548 1,080 122,628 316,982 2,166 319,148
Cost of goods sold65,738 (937)64,801 181,475 (10,519)170,956
Gross margin55,810 2,017 57,827 135,507 12,685 148,192
Gross margin91,430 274,440 (3,093)271,347
Cost of goods sold47,246 988 48,234 140,387 1,786 142,173
Gross margin45,017 (1,821)43,196 134,053 (4,879)129,174
Gross margin13,197 39,285 (627)38,658
General and administrative12,110 (188)11,922 34,747 (1,036)33,711
Research and development5,153 219 5,372 15,939 (150)15,789
Amortization of intangible assets11,179 (18)11,161 33,725 (18)33,707
Operating income (loss)3,203 (1,659)1,544 10,357 (3,048)7,309


Select financial results excluding the impact of hyperinflation under IAS 29
1

Change Change
Q3-25Q3-24$%YTD-25YTD-24$%
Adjusted Revenues122,628 91,430 31,198 34%319,148 271,347 47,801 18%
Cost of goods sold64,801 48,234 (16,567)34%170,956 142,173 (28,783)20%
Gross margin57,827 43,196 14,631 34%148,192 129,174 19,018 15%
Gross margin38%48,001 38,658 (9,343)24%
General and administrative12,694 11,922 (772)6%40,178 33,711 (6,467)19%
Research and development8,855 5,372 (3,483)65%20,142 15,789 (4,353)28%
Amortization of intangible assets15,446 11,161 (4,285)38%35,651 33,707 (1,944)6%
Operating income2,676 1,544 1,132 73%4,220 7,309 (3,089)42%
Adjusted EBITDA120,987 13,454 7,533 56%48,607 42,787 5,820 14%
Adjusted EBITDA1(%)17%15% 15%16%
Adjusted EBITDA per share10.21 0.13 0.08 62%0.49 0.42 0.07 17%

1 Adjusted EBITDA, Adjusted EBITDA per share and financial results excluding the impact of IAS 29 are non-GAAP measures and do not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

Adjusted Revenues1 by Therapeutic Area

Change Change
Therapeutic AreaQ3-25Q3-24$%YTD-25YTD-24$%
Oncology/Hematology38,28236,8211,4614%105,406103,2882,1182%
Infectious Diseases37,22533,8263,39910%118,965109,7149,2518%
Other Specialty47,12120,78326,338127%94,77758,34536,43262%
Total122,62891,43031,19834%319,148271,34747,80118%

1 Excluding the impact of hyperinflation under IAS 29. Adjusted Revenues is a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

[ii] Financial results at constant currency

Financial results at constant currency are obtained by translating the prior period revenues and financial results from the functional currencies to CAD using the conversion rates in effect during the current period. Furthermore, with respect to Argentina, the Company excludes the impact of hyperinflation and translates the revenues and results at the average exchange rate in effect for each of the periods.

The Company believes that financial results at constant currency represents a useful measure to investors because it eliminates the effect that foreign currency exchange rate fluctuations may have on period-to-period comparability given the volatility in foreign currency exchange markets and therefore, provides greater transparency to the underlying performance of our consolidated financial results. The presentation of revenues and financial results under constant currency is considered to be a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

The following tables are reconciliations of financial results under IFRS to financial results and financial results at constant currency.

Q3-24YTD-24
Excluding the impact of IAS 291Constant Currency AdjustmentConstant CurrencyExcluding the impact of
IAS 291
Constant Currency AdjustmentConstant Currency
Adjusted Revenues91,430 1,87493,304 271,347 (7,021)264,326
Cost of goods sold48,234 95149,185 142,173 (4,123)138,050
Gross margin43,196 92344,119 129,174 (2,898)126,276
Gross margin37,894
General and administrative11,922 13112,053 33,711 (113)33,598
Research and development5,372 665,438 15,789 (211)15,578
Amortization of intangible assets11,161 7811,239 33,707 651 34,358
Operating income (loss)1,544 4221,966 7,309 (2,461)4,848

1 Refer to Subsection - [i] Financial results excluding the impact of hyperinflation under IAS 29 for additional details.

Select financial results at Constant Currency1

Three-month period ended
September 30,
Nine-month period ended
September 30,
Excluding impact of IAS 29
Constant Currency1Change Constant Currency1Change
2025 2024 $%2025 2024 $%
Adjusted Revenues122,628 93,304 29,324 31%319,148 264,326 54,822 21%
Cost of goods sold64,801 49,185 (15,616)32%170,956 138,050 (32,906)24%
Gross margin57,827 44,119 13,708 31%148,192 126,276 21,916 17%
Gross margin35%48,001 37,894 (10,107)27%
General and administrative12,694 12,053 (641)5%40,178 33,598 (6,580)20%
Research and development8,855 5,438 (3,417)63%20,142 15,578 (4,564)29%
Amortization of intangible assets15,446 11,239 (4,207)37%35,651 34,358 (1,293)4%
Operating income (loss)2,676 1,966 710 36%4,220 4,848 (628)13%
Adjusted EBITDA120,987 13,955 7,032 50%48,607 40,978 7,629 19%
Adjusted EBITDA1(%)17%15% 15%16%
Adjusted EBITDA per share10.21 0.14 0.07 53%0.49 0.40 0.08 21%

1 EBITDA, Adjusted EBITDA, Adjusted EBITDA per share and financial results at constant currency are a non-GAAP measures and do not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

Adjusted Revenues at Constant Currency1 by Therapeutic Area

Three-month period ended
September 30,
Nine-month period ended
September 30,
Excluding impact of IAS 29
Constant Currency1 Constant Currency1
Innovative20252024$%20252024$%
Oncology/Hematology38,28237,5936892%105,406101,6603,7464%
Infectious Diseases37,22534,9692,2566%118,965106,12912,83612%
Other Specialty47,12120,74226,379127%94,77756,53738,24068%
Total122,62893,30429,32431%319,148264,32654,82221%

1 Adjusted Revenues at constant currency is a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

[iii] Adjusted Gross Margin
Adjusted Gross Margin is defined as revenues less cost of goods sold, adjusted for the impact of IAS 29 (accounting under hyperinflation) and the impact in cost of goods sold of the difference between the fair value of inventory acquired and the cost paid in the Paladin Transaction, accounted under IFRS 3 - Business Combinations, when the inventory acquired as part of the transaction is sold ("Step-Up Expense").

The Company believes that Adjusted Gross Margin represents a useful measure to investors as allow Gross Margin to be viewed without the impact of hyperinflation under IAS 29 and Step-Up Expense, thereby facilitating the comparison period over period. The presentation of Adjusted Gross Margin is considered to be a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

Change Change
Q3-25Q3-24$%YTD-25YTD-24$%
Gross margin55,810 45,017 10,79324%135,507 134,053 1,4541%
Adjustments to gross margin:
Impact of IAS 292,017 (1,821)3,838211%12,685 (4,879)17,564360%
Step-Up Expense2,071 - 2,071-%2,231 - 2,231-%
Adjusted Gross Margin59,898 43,196 16,70239%150,423 129,174 21,24916%
Adjusted Gross Margin80%(8,560)10,357 (18,917)183%
Adjustments to operating income (loss):
Amortization of intangible assets15,446 11,179 4,267 38%35,651 33,725 1,926 6%
Depreciation of property, plant and equipment and ROU assets2,322 2,210 112 5%5,839 5,414 425 8%
Lease payments(1,200)(997)(203)20%(3,385)(2,861)(524)18%
EBITDA17,214 15,595 1,619 10%29,545 46,635 (17,090)37%
Impact of IAS 291,479 (2,265)3,744 165%11,521 (4,075)15,596 383%
Acquisition and transaction costs170 18 152 844%4,631 121 4,510 3727%
Step-Up Expense2,071 - 2,071 -%2,231 - 2,231 -%
Other non-recurring expenses53 106 (53)50%679 106 573 541%
Adjusted EBITDA20,987 13,454 7,533 56%48,607 42,787 5,820 14%
Adjusted EBITDA per share0.21 0.13 0.08 62%0.49 0.42 0.07 17%

For the quarter ended September 30, 2025, adjusted EBITDA increased by $7,533 or 56%. The increase was mainly driven by higher Adjusted Gross Margin, partly offset by higher costs related to the Paladin and Sumitomo Transactions and the increase in our promotional activities behind our pipeline and early launch products.

Explanation of adjustments from EBITDA to Adjusted EBITDA

Impact of IAS 29Impact of hyperinflation accounting under IAS 29 over the operating income (loss).
Acquisition and transaction costsNon-capitalizable acquisition and transaction costs relate to costs incurred on legal, consulting and advisory fees for the acquisitions.
Step-Up ExpenseStep-up expense relates to the impact in cost of goods sold of the difference between the fair value of inventory acquired and the cost paid in a transaction, accounted under IFRS 3 - Business Combinations, when the inventory acquired as part of the transaction is sold.
Other non-recurring expensesOther non-recurring expenses relate to expenses incurred by the Company that are not due to, and are not expected to occur in, the ordinary course of business.


[vi] Adjusted EBITDA per share

Adjusted EBITDA per share is defined as Adjusted EBITDA over number of common shares outstanding at the end of the respective period.

The Company believes that Adjusted EBITDA per share represents a useful measure to investors to assess profitability and measure the Company's ability to generate liquidity through operating activities on a per common share basis, without the impact of hyperinflation under IAS 29, acquisition and transaction costs, Step-Up Expense and non-recurring expenses, thereby facilitating the comparison period over period. The presentation of adjusted EBITDA per share is considered to be a non-GAAP ratio and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

The Company calculated adjusted EBITDA per share as follows:

Q3-25Q3-24YTD-25YTD-24
Adjusted EBITDA20,98713,45448,60742,787
Adjusted EBITDA per share0.210.130.490.42
Number of common shares outstanding at period end (in thousands)99,678100,97699,678100,976
INTERIM CONSOLIDATED BALANCE SHEETS
[In thousands of Canadian dollars]
[Unaudited]
As atSeptember 30, 2025December 31, 2024
ASSETS


Current
Cash and cash equivalents81,87680,106
Marketable securities13,68262,225
Trade receivables117,890105,196
Other receivables8,1494,339
Inventories144,401102,698
Prepaids and deposits8,0167,744
Other current financial assets22,58330,506
Income taxes receivable4,0983,999
Total current assets400,695396,813
Prepaids and deposits9,2047,217
Right-of-use assets9,6515,912
Property, plant and equipment12,12714,110
Intangible assets377,417283,612
Goodwill92,23986,477
Other financial assets71,909103,426
Deferred tax assets29,93321,247
Other long-term receivables45,40144,983
Total non-current assets647,881566,984
Total assets1,048,576963,797
INTERIM CONSOLIDATED BALANCE SHEETS (continued)
[In thousands of Canadian dollars]
[Unaudited]
As atSeptember 30, 2025December 31, 2024
LIABILITIES AND SHAREHOLDERS' EQUITY
Current
Accounts payable and accrued liabilities112,85278,345
Lease liabilities3,7352,640
Other liabilities9,7051,876
Bank loans17,80517,486
Income taxes payable475213
Other balances payable8,10410,688
Total current liabilities152,676111,248
Accounts payable and accrued liabilities5,2764,828
Lease liabilities5,9623,434
Bank loans78,74025,899
Other balances payable36,28519,443
Deferred tax liabilities2,8453,840
Total liabilities281,784168,692
Shareholders' equity
Share capital532,792534,266
Warrants-117
Contributed surplus29,52225,708
Accumulated other comprehensive income64,05780,220
Retained earnings140,421154,794
Total shareholders' equity766,792795,105
Total liabilities and shareholders' equity1,048,576963,797
INTERIM CONSOLIDATED STATEMENTS OF INCOME (LOSS)
[In thousands of Canadian dollars, except for share and per share amounts]
[Unaudited]
Three months ended
September 30,
Nine months ended
September 30,
2025 2024 2025 2024
Revenues121,548 92,263 316,982 274,440
Cost of goods sold65,738 47,246 181,475 140,387
Gross margin55,810 45,017 135,507 134,053
Gross margin %46%49%43%49%
Expenses
Selling and marketing17,908 13,372 47,506 39,285
General and administrative13,116 12,110 41,149 34,747
Research and development8,694 5,153 19,761 15,939
Amortization of intangible assets15,446 11,179 35,651 33,725
Operating income (loss)646 3,203 (8,560)10,357
Interest income on financial instruments measured at amortized cost(1,094)(2,458)(4,943)(6,554)
Other interest income(13)(65)(44)(1,194)
Interest expense2,368 1,915 6,498 6,776
Other expense (income)271 (795)2,601 (1,006)
Net loss on financial assets measured at fair value through profit or loss4,589 2,820 11,271 19,752
Foreign exchange (gain) loss(3,124)2,326 (4,116)5,934
Gain on hyperinflation(434)(1,148)(1,901)(7,528)
Income (loss) before income taxes(1,917)608 (17,926)(5,823)
Income taxes
Current2,035 1,862 2,704 4,776
Deferred(161)(1,339)(6,402)(4,196)
Income tax expense (recovery)1,874 523 (3,698)580
Net (loss) income for the period(3,791)85 (14,228)(6,403)
Basic and diluted net loss per share(0.04)- (0.14)(0.06)
Basic and diluted weighted average number of common shares outstanding99,657,996 101,132,799 99,643,135 101,211,415
INTERIM CONSOLIDATED STATEMENTS OF CASH FLOWS
[In thousands of Canadian dollars]
[Unaudited]
Three months ended
September 30,
Nine months ended
September 30,
2025 2024 2025 2024
OPERATING ACTIVITIES
Net (loss) income for the period(3,791)85 (14,228)(6,403)
Adjustments reconciling net income to operating cash flows:
Depreciation and amortization17,768 13,389 41,490 39,139
Net loss on financial instruments4,589 2,820 11,271 19,752
Unrealized foreign exchange (gain) loss1,423 98 1,254 (6,231)
Other operating activities1,560 (384)4,224 (4,030)
21,549 16,008 44,011 42,227
Changes in non-cash working capital and other items(11,386)(10,992)(9,926)(7,416)
Cash inflow from operating activities10,163 5,016 34,085 34,811
INVESTING ACTIVITIES
Acquisition of Paladin(3,196)- (110,081)-
Purchase of marketable securities(3,094)(45,417)(16,976)(123,339)
Proceeds on maturity of marketable securities3,059 58,703 64,686 150,693
Investment in funds(759)(1,372)(894)(2,575)
Purchase of intangible assets(2,401)(1,671)(30,237)(28,488)
Other investing activities4,985 1,284 22,928 2,623
Cash (outflow) inflow from investing activities(1,406)11,527 (70,574)(1,086)
FINANCING ACTIVITIES
Repurchase of common shares through Normal Course Issuer Bid- (2,474)(3,351)(3,716)
Principal repayment of bank loans(3,810)(2,039)(60,214)(10,698)
Proceeds from bank loans- 1,638 111,203 2,930
Other financing activities(2,099)(1,052)(7,434)(6,702)
Cash (outflow) inflow from financing activities(5,909)(3,927)40,204 (18,186)
Increase in cash and cash equivalents during the period2,848 12,616 3,715 15,539
Cash and cash equivalents, beginning of the period77,816 60,807 80,106 58,761
Net foreign exchange difference1,212 332 (1,945)(545)
Cash and cash equivalents, end of the period81,876 73,755 81,876 73,755
Cash and cash equivalents81,876 73,755 81,876 73,755
Marketable securities13,682 77,745 13,682 77,745
Total cash, cash equivalents and marketable securities95,558 151,500 95,558 151,500

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