NEW YORK CITY (dpa-AFX) - Bayer AG, Bristol-Myers Squibb Co.(BMY) and Ono Pharmaceutical Co., Ltd. announced Thursday that the three companies entered into a clinical collaboration.
As per the agreement, the companies would evaluate the combination of Bayer's kinase inhibitor Stivarga or regorafenib and Bristol-Myers Squibb's / Ono's anti-PD-1 immune checkpoint inhibitor, Opdivo or nivolumab in patients with micro-satellite stable metastatic colorectal cancer.
Earlier, the phase III study has shown limited response and hence combination apporoaches were high. In a Phase 1b, the combination of regorafenib and nivolumab has shown promising preliminary efficacy results.
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