WASHINGTON (dpa-AFX) - Seelos Therapeutics Inc. (SEEL) announced encouraging preclinical data from an in vivo study of SLS-005 (trehalose injection, 90.5 mg/mL for intravenous infusion) in an aggressive Alzheimer's disease non-human primate model.
In Wednesday pre-market trade, SEEL was trading at $0.18 up $0.002 or 1.124%
In this study, the overexpression of tau in older non-human primates (NHPs) was utilized through bilateral AAV induced tauopathy. Non-human primates in this study were administered either SLS-005 weekly, a single administration of SLS-009 or control.
The NHPs receiving SLS-005 demonstrated a 46% reduction in tau protein and an 18% reduction in neurofilament light chain or NfL protein biomarker from baseline values in a preliminary analysis.
NfL is a non-specific biomarker for several neurodegenerative conditions, including Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS).
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