Novartis Pharma AG: New Novartis data at ASN Kidney Week and AHA Scientific Sessions demonstrate momentum of broad CRM portfolio and pipeline

• Fabhalta and Vanrafia Phase III analyses, Fabhalta real-world treatment pattern data, and zigakibart Phase I/II trialshowcase strength of IgA nephropathy (IgAN) portfolio
  
  
• C3 glomerulopathy (C3G) studies add to body of evidence of Fabhalta long-term safety and efficacy profile in native and post-transplant disease recurrence patients
  
  
• V-INCEPTION analyses highlight Leqvio adherence and goal attainment data when initiated early in post-acute coronary syndrome patients
  
  
• Lp(a) data underscore importance of early detection of this independent CVD risk factor in premature ASCVD patients and potential benefit of Lp(a)-targeted therapies
  
  

Basel, November 4, 2025 - Novartis will present new data from 33 abstracts across its Cardiovascular, Renal, and Metabolic (CRM) disease portfolio at the upcoming American Society of Nephrology (ASN) Kidney Week 2025 in Houston, Texas and American Heart Association's (AHA) Scientific Sessions 2025 in New Orleans, Louisiana, advancing scientific insight into these critical disease areas.

"Novartis will present a broad range of data at ASN and AHA demonstrating innovation and commitment to advancing therapies that address root causes of heart and kidney conditions," said Ruchira Glaser, M.D., Global Head, Cardiovascular, Renal and Metabolic Development Unit, Novartis. "Studies on both our approved and investigational therapies in these closely connected therapeutic areas reflect our longstanding dedication to deliver meaningful solutions for patients living with some of the rarest to most prevalent CRM diseases worldwide."

Key highlights of data accepted by ASN include:

Abstract Title		Abstract Number/Presentation Details
Fabhalta® (iptacopan)
Efficacy and Safety of Iptacopan in Patients (Pts) from East Asia with IgAN: Interim Results from the Phase 3 APPLAUSE-IgAN Trial		Abstract PO0811 Poster Presentation November 7, 10:00 AM - 12:00 PM CT
Early Insights into Characteristics and Treatment Patterns of US Patients (Pts) with IgAN Who Were Prescribed Iptacopan: The APPRISE-IgAN Data Platform		Abstract PO0771 Poster Presentation November 8, 10:00 AM - 12:00 PM CT
Efficacy and Safety of Iptacopan in Patients with C3 Glomerulopathy: C3G Extension Trial Interim Results from the Phase 3 APPEAR-C3G Patients		Abstract PO0838 Poster Presentation November 7, 10:00 AM - 12:00 PM CT
Update to the Long-Term Efficacy and Safety of Iptacopan in C3 Glomerulopathy: 39-Month Phase 2 Extension Study Data		Abstract PO0837 Poster Presentation November 7, 10:00 AM - 12:00 PM CT
Iptacopan Treatment in Patients with C3 Glomerulopathy (C3G): 12-Month Results from the Early Access Program		Abstract PO0811 Poster Presentation November 8, 10:00 AM - 12:00 PM CT
Vanrafia® (atrasentan)
Renin-Angiotensin System Inhibitor (RASi) Use and Atrasentan in IgAN: Post Hoc Analysis from the ALIGN Trial		Abstract PO0827 Poster Presentation November 7, 10:00 AM - 12:00 PM CT
Efficacy and Safety of Atrasentan in Patients (Pts) with IgAN from East (E) Asia: Phase 3 ALIGN Interim Data		Abstract OR034 Oral Presentation November 7, 5:30 - 5:40 PM CT
Zigakibart
Long-Term Stabilization of Kidney Function Regardless of Baseline eGFR and Urine Protein-to-Creatinine Ratio (UPCR) in Patients with IgAN: Subgroup Analyses from the Phase 1/2 Trial of Zigakibart		Abstract PO0814 Poster Presentation November 7, 10:00 AM - 12:00 PM CT
SHIFT: A Kidney Biopsy Study in Adults with IgAN Treated with Zigakibart		Abstract INFO18 Informational Poster November 7, 10:00 AM - 12:00 PM CT
Farabursen
Farabursen Increases Urinary Polycystin-1 and Polycystin-2 and Reduces Height-Adjusted Total Kidney Volume Growth in Patients with ADPKD		Abstract OR089 Oral Presentation November 8, 4:30 PM - 6:00 PM CT

Key highlights of data accepted by AHA include:

Abstract Title		Abstract Number/Presentation Details
Leqvio® (inclisiran)*
Effect Of Inclisiran-based Treatment Strategy, In Combination With Individually Optimized Statin Therapy, On Quality Of Life And Muscle-related Pain vs. Standard of Care: Exploratory Outcomes From The VICTORION-Difference Study		Abstract MP1723 Moderated Digital Poster Presentation November 9, 12:25 PM - 12:30 PM CT
VICTORION-INCEPTION: Adherence and Goal Attainment Data Support the Addition of Inclisiran to Background Lipid-Lowering Therapy as a Lipid Management Strategy Post-Acute Coronary Syndrome		Abstract MP1492 Moderated Digital Poster Presentation November 9, 10:18 AM - 10:23 AM CT
VICTORION-INCEPTION: Consistent Low-Density Lipoprotein Cholesterol Lowering With Inclisiran Following Acute Coronary Syndrome Independent of Index Lipid-Lowering Therapy		Abstract Mo2111 Poster Presentation November 10, 1:00 PM - 2:00 PM CT
Primary Results of the VICTORION-NOVEL (LDL-C maNagement PrOgram in Atherosclerotic Cardiovascular Disease (ASCVD) Patients with Elevated LDL-C) Lipid Optimization Multicenter Implementation Trial		Abstract MP2380 Moderated Digital Poster Presentation November 10, 1:59 PM - 2:04 PM CT
Lipoprotein(a)
Overcoming Barriers For Research Participation In Minority Patients In Lp(a)FRONTIERS EXPANSION: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate Efficacy And Safety Of Pelacarsen In U.S. Black And Hispanic Patients with Elevated Lp(a) And Established ASCVD		Abstract MP913 Moderated Digital Poster Presentation November 8, 1:45 PM - 1:50 PM CT
Elevated Lipoprotein(a) Is Independently Associated With Greater Infarct Size, Especially in Premature Atherosclerosis		Abstract MP376 Moderated Digital Poster Presentation November 8, 9:50 AM - 9:55 AM CT
Impact of Elevated Lipoprotein(a) on Cardiovascular Events in Patients with premature ASCVD: A Nationally Representative Sample of US Medicare, Medicaid, and Commercial Enrollees		Abstract MP2201 Moderated Digital Poster Presentation November 10, 2:20 PM - 2:25 PM CT
Pacibekitug**
A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Monthly or Quarterly Subcutaneous Administration of the Interleukin-6 Inhibitor Pacibekitug in Patients With Elevated High-Sensitivity C-Reactive Protein and Chronic Kidney Disease: 90-Day Analyses from TRANQUILITY		Abstract # MP1719 Moderated Digital Poster Presentation November 9, 11:57 AM - 12:02 PM CT

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Novartis in cardiovascular, renal, and metabolic disease
Novartis is redefining how the world tackles cardiovascular, renal, and metabolic (CRM) conditions because interconnected diseases require interconnected thinking. We are continuing our 40-year legacy in both cardiovascular (CV) and renal with our bold science, robust portfolio, and growing pipeline. In cardiovascular care, we envision a world with no preventable CV deaths and are using cutting-edge science and technology in our mission to ensure no heart is lost too soon. In kidney disease, we are building on our groundbreaking work that began in transplant, with an expanding portfolio of medicines that target the underlying causes of disease, starting with kidney conditions that have significant unmet need. Together, we are breaking boundaries - to transform outcomes, improve lives, and build a better world for people with CRM diseases.

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*Novartis has obtained global rights to develop, manufacture and commercialize Leqvio under a license and collaboration agreement with Alnylam Pharmaceuticals, a leader in RNAi therapeutics.

**Complementing its cardiovascular pipeline, Novartis recently acquired Tourmaline Bio, a clinical-stage biopharmaceutical company developing pacibekitug, a Phase III-ready anti-IL-6monoclonal antibody for atherosclerotic cardiovascular disease (ASCVD).

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