- The REVERT Phase 1b/2a clinical trial evaluating OPM-101 in patients with advanced melanoma resistant to anti-PD1 has been submitted to the Swiss regulatory (Swissmedic) and ethics (Swiss ethics) authorities
- OPM has reintegrated, in close collaboration with Servier, all data and product stocks for OPM-201
- Appointment of Christophe THURIEAU, Chief Research Officer at Servier, as an independent director
- Establishment of a maximum €5 million equity financing line with IRIS
- Cost reduction plan rolled out in the first half of 2025
- OPM's half-year net income thus stands at €9.8 million, due to the integration of OPM-201 inventories valued at €13 million by an external expert
- Cash position of €2.5 million as of June 30, 2025, reinforced in July 2025 by the receipt of €1.1 million in research tax credits
- €1.7 million in R&D investments in our programs, mainly in the clinical development of OPM-101
Regulatory News:
Oncodesign Precision Medicine (OPM) (ISIN: FR001400CM63; Mnemonic: ALOPM), a biopharmaceutical company specializing in precision medicine for the treatment of resistant and metastatic cancers, announces its financial results for the first half of 2025, as approved by the Board of Directors on July 31, 2025.
Philippe GENNE, Chairman and CEO of Oncodesign Precision Medicine, comments: "To date, it remains impossible to raise funds on Euronext for a biotechnology company that needs to conduct clinical proof-of-concept trials. As a result, our hopes for revenue and therefore cash availability rest primarily on discussions with potential buyers of our assets. The various cost-cutting measures we have taken since the beginning of this year are enabling us to continue these discussions over time, and the last quarter will be crucial in this regard."
Karine LIGNEL, Managing Director and COO of Oncodesign Precision Medicine adds: "In a very difficult financial environment, we have taken management decisions that have enabled us to significantly reduce our expenses and thus extend our cash flow horizon as much as possible. We have also set up an equity financing line to deal with market uncertainties. Nevertheless, the situation remains complicated, and we are making every effort to secure a partnership for one of our assets."
Oncodesign Precision Medicine Income Statement | ||||
in M€
| H1 2025 | H1 2024 | Evolution | |
In % | in value | |||
Revenues | 0.14 | 0.14 | 0% | +0.00 |
Other revenues and operating income | 0.60 | 0.50 | 21% | +0.10 |
Total revenues and operating income | 0.74 | 0.64 | 16% | +0.10 |
Stock variation | 13.00 | NS | +13.00 | |
Purchases consumed | (2.24) | (3.33) | -33% | +1.09 |
Personnel costs | (1.51) | (1.35) | 12% | -0.16 |
Other operating expenses | (0.02) | (0.03) | -19% | +0.01 |
Taxes and duties | (0.03) | (0.03) | 19% | -0.01 |
Net change in depreciation and amortization | (0.15) | (0.13) | 16% | -0.02 |
Total operating expenses | 9.05 | (4.86) | NS | +13.91 |
Operating result | 9.79 | (4.22) | -332% | +14.01 |
Financial income and expenses | (0.26) | (0.06) | 342% | -0.20 |
Income from ordinary activities of consolidated companies | 9.53 | (4.28) | -323% | +13.81 |
Extraordinary income and expenses | 0 | (0.01) | NS | +0.01 |
Income tax | 0.31 | 0.65 | -52% | -0.34 |
Net result | 9.85 | (3.64) | NS | +13.48 |
Key financial data
A cost reduction program was implemented in the first half of 2025:
- Negotiations were held with the banks and BPI that granted the loan, resulting in a six-month deferral of principal repayments starting in April 2025
- Expenses were reduced through
- The layoff of five employees in early 2025
- A 50% reduction in the compensation of non-salaried corporate officers
- A freeze on salaries and bonus payments for the 2024 fiscal year
- A reduction in spending on non-priority programs.
In terms of cash flow, rather than from an accounting perspective, this results in a reduction in payroll costs of €242k in the first half of 2025 and a projected reduction of €440k in the second half of this year. The reduction in expenditure is particularly significant for the item "subcontracting and fees," which will fall from €2,900k in the first half of 2024 to €1,773k in the first half of 2025.
R&D expenses amounted to €1.74 million in the first half of 2025, compared with €3.61 million in the same period last year, as the company focused its efforts on the clinical development of OPM-101.
Oncodesign Precision Medicine R&D expenditure | ||||
in M€
| H1 2025 | H1 2024 | Evolution | |
In % | in value | |||
Partnerships | 0.46 | 0.68 | -32% | -0.2 |
Licensing | 1.28 | 2.93 | -56% | -1.7 |
Total R&D expenses | 1.74 | 3.61 | -52% | -1.9 |
Reintegration, in close collaboration with Servier, of all OPM-201 data and product stocks
The most significant financial item in the first half of 2025 is the reintegration, as provided for in the partnership agreement, of the stock of OPM-201 GMP material produced by Servier. As this reintegration is being carried out without financial competing, OPM has called upon an external expert to determine fair value for these stocks. This expert carried out three different valuations to arrive at this fair value.
A summary of these valuations is shown in the table below:
in M€ | Min. | Centrale | Max. |
Valuation of inventories based on cost price | 7.2 | 7.2 | 7.2 |
Valuation of inventories using the "milestone economy" method | 13.0 | 13.0 | 13.0 |
Valuation of inventories using rNPV discounting | 15.3 | 15.7 | 16.2 |
The expert concluded that the fair value of these inventories falls within a range of €13 million to €16.2 million. OPM used the lower end of this range.
OPM's revenue for the first half of 2025 was €0.1 million, the same as in the first half of 2024.
Other income mainly consists of subsidies amounting to €0.3 million and €0.3 million in provision reversals.
OPM's financial result was (€0.26) million, compared with (€0.1) million in the same period last year, mainly due to interest on outstanding loans and financial income from cash investments.
OPM recorded €0.4 million in R&D tax credits in the first half of 2025, down 52% compared to last year. The amount of R&D tax credits was reduced by the amount of public aid, the R&D expenditure base decreased, and the rules for collecting R&D tax credits changed (exclusion of technology watch patents, etc.).
OPM's half-year net income thus stands at €9,846k, due to the integration of OPM-201 inventories at an estimated value of €13m.
Cash position of €2.5m at June 30, 2025
As of June 30, 2025, OPM had cash reserves of €2.5 million, before receiving the Research Tax Credit, compared to €9.6 million (including the Research Tax Credit) as of June 30, 2024.
The Research Tax Credit, amounting to €1.1 million, was received in July 2025.
OPM has access to a maximum €5 million equity financing facility, which it has not yet used. The Company is in discussions with financial and pharmaceutical partners with the goal of signing a partnership agreement or raising funds.
2025 perspectives
OPM has submitted its Phase 1b/2a protocol for the REVERT study evaluating OPM-101 in patients with advanced melanoma resistant to anti-PD1 and is awaiting a response from Swiss ethics institutions. The first patient is expected to be enrolled by the end of 2025.
Work on radioligands is continuing as part of the COMETE project.
Partnership prospects or transfer mainly focus on the two most advanced molecules to date (OPM-101 and OPM-201).
OPM's goal is to license or transfer OPM-101 at the end of Phase 2a to a pharmaceutical partner who will complete its development and commercialization. While we do not anticipate licensing or sales before the end of this phase in 2027, we are considering the possibility of a pharmaceutical partner taking a licensing option with the payment of an exclusivity fee, giving them first refusal on the results.
For OPM-201, the objective is to find a partnership similar to the one we found with Servier in 2019 or a buyer.
Availability of the 2025 half-year financial report
The 2025 half-year financial report will be available on the company's website, within the legal deadline, before October 31, 2025.
About Oncodesign Precision Medicine (OPM)
Oncodesign Precision Medicine (OPM), founded in 2022, is a biopharmaceutical company specializing in precision medicine, dedicated to discovering treatments for resistant and metastatic cancers.
OPM currently has two kinase inhibitors in clinical phase: OPM-101, intended for the treatment of chronic immuno-inflammatory digestive diseases and immuno-oncology, has demonstrated a significant therapeutic margin and absence of toxicity in its phase I healthy volunteers, with the start of phase 1b/2a in Oncology scheduled for early 2025. OPM-201, initially licensed to Servier and intended for the treatment of Parkinson's disease, completed its phase I trial in healthy volunteers at the end of 2024, and was reintegrated into OPM's portfolio.
Both molecules come from the Nanocyclix technology platform, which enables the design and selection of small, highly effective and selective macrocyclic kinase inhibitors. We now have 12,000 molecules in our library and will be using AI to accelerate the discovery of drug candidates while reducing the cost of this phase.
OPM's other two technology platforms are:
- OncoSNIPER, for the selection of therapeutic targets using artificial intelligence, on which we have a partnership with Servier for the search for targets in pancreatic cancer,
- PROMETHE for the design and selection of radiolabeled biological molecules for systemic radiotherapy, on which we are currently discussing partnerships with vectorization manufacturers.
OPM, co-founded by Philippe Genne, Jan Hoflack and Karine Lignel, is based in Dijon, at the heart of the university and hospital cluster, and employs 14 people.
More info at: oncodesign.com
Forward-looking statements
This document contains forward-looking statements and estimates with respect to the financial condition, results of operations, strategy, plans and future performance of the Company and the market in which it operates. Some of these statements, forecasts and estimates can be identified by the use of words such as, without limitation, "believes", "anticipates", "expects", "projects", "plans", "seeks", "estimates", "may", "will" and "continue" and other similar expressions. They include all matters that are not historical facts. Such statements, forecasts and estimates are based on various assumptions and assessments of known and unknown risks, uncertainties and other factors, which were believed to be reasonable when they were made but which may not prove to be correct. Actual events are difficult to predict and may depend on factors beyond the Company's control. Consequently, the actual results, financial conditions, performance or achievements of the Company, or industry results, may differ materially from future results, performance or achievements as expressed or implied by such statements, forecasts and estimates. Given these uncertainties, no representation is made as to the accuracy or fairness of such forward-looking statements, forecasts and estimates. Furthermore, the forward-looking statements, forecasts and estimates speak only as of the date of publication of this document. The Company disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any change in the Company's expectations with regard thereto, or any change in events, conditions or circumstances on which these statements, forecasts or estimates are based, except as required by French law.
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Contacts:
OPM
Karine Lignel
Deputy General Manager
Tel: +33 (0)310 451 820
investisseurs@oncodesign.com
NewCap
Investor Relations
Mathilde Bohin Alban Dufumier
Tel: +33 (0)1 44 71 94 95
oncodesign@newcap.eu
NewCap
Media Relations
Arthur Rouillé
Tel: +33 (0)1 44 71 00 15
oncodesign@newcap.eu
